Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 8/20 | 0.40 |
| ▸ | CASP3 | P42574 | 13/20 | 0.39 |
| ▸ | CASP8 | Q14790 | 8/20 | 0.39 |
| ▸ | CASP7 | P55210 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7277260 | 0.94 | CASP1 (0.41) | CASP1CASP3CASP8CASP7MEN1 | |
| SCHEMBL7285059 | 0.91 | CASP3 (0.44) | CASP1CASP3CASP8CASP7 | |
| SCHEMBL7414938 | 0.84 | KMT2A (0.35) | CASP1CASP3CASP8CASP7MEN1 | |
| SCHEMBL7277122 | 0.83 | CASP1 (0.51) | CASP1 | |
| SCHEMBL7277381 | 0.82 | CASP1 (0.58) | CASP1CASP3 | |
| SCHEMBL7301728 | 0.82 | CTSC (0.47) | MEN1KMT2A | |
| SCHEMBL7284655 | 0.77 | CASP1 (0.44) | CASP1CASP3 | |
| SCHEMBL7275911 | 0.76 | CASP1 (0.52) | CASP1CASP3 | |
| SCHEMBL7423470 | 0.72 | F2 (0.41) | — | |
| SCHEMBL7286999 | 0.72 | CASP1 (0.62) | CASP1CASP3CASP8CASP7CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519748-A2 | Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme | MERCK & CO. INC. (US) | 1992-12-23 | — | — | EP | claimed |
| EP-0519748-B1 | Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme | MERCK & CO INC (US) | 1998-09-02 | — | — | EP | disclosed |
| US-5434248-A | Peptidyl derivatives as inhibitors of interleukin-1β converting enzyme | MERCK & CO., INC. (US) | 1995-07-18 | — | — | US | disclosed |
| EP-0519748-A2 | Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme | MERCK & CO. INC. (US) | 1992-12-23 | — | — | EP | disclosed |