Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 8/20 | 0.49 |
| ▸ | DRD2 | P14416 | 7/20 | 0.37 |
| ▸ | DRD3 | P35462 | 5/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284819 | 0.96 | NAMPT (0.45) | NAMPTDRD2DRD3DRD4OPRM1 | |
| SCHEMBL7275479 | 0.93 | NAMPT (0.52) | NAMPTDRD2DRD3DRD4OPRM1 | |
| SCHEMBL7286583 | 0.89 | NAMPT (0.47) | NAMPTDRD2DRD3DRD4OPRM1 | |
| Hydrochloric Acid SCHEMBL7335027 | 0.86 | ITGB3 (0.37) | NAMPTGPR183 | |
| Hydrochloric Acid SCHEMBL7277393 | 0.86 | ITGB3 (0.37) | NAMPTGPR183 | |
| SCHEMBL7284718 | 0.82 | HTR1A (0.42) | NAMPTDRD2DRD3DRD4HTR1A | |
| SCHEMBL7273026 | 0.81 | NAMPT (0.40) | NAMPTDRD2DRD3DRD4OPRM1 | |
| Hydrochloric Acid SCHEMBL7276227 | 0.81 | ITGB3 (0.36) | OPRM1MTNR1A | |
| SCHEMBL7274972 | 0.81 | NAMPT (0.40) | NAMPTDRD2DRD3DRD4HTR1A | |
| SCHEMBL7283192 | 0.80 | NR1H2 (0.40) | NAMPTOPRM1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528369-B1 | Cyclic imino derivatives, pharmaceutical compositions containing them and process for their preparation | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-11-24 | — | — | EP | disclosed |
| EP-0528369-A2 | Cyclic imino derivatives, pharmaceutical compositions containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-02-24 | — | — | EP | disclosed |