Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 3/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7285483 | 0.94 | NR1H2 (0.41) | NR1H2KDM4EPKMNAMPTESR2 | |
| SCHEMBL7276445 | 0.94 | NAMPT (0.40) | KDM4EPKMNAMPTSIGMAR1HTR1A | |
| SCHEMBL7286896 | 0.93 | NAMPT (0.39) | NR1H2KDM4EPKMNAMPTESR2 | |
| SCHEMBL7286501 | 0.91 | KDM4E (0.43) | NR1H2KDM4EPKMESR2SIGMAR1 | |
| SCHEMBL7277905 | 0.89 | KDM4E (0.41) | KDM4EPKMNAMPTSIGMAR1HTR1A | |
| SCHEMBL7285724 | 0.88 | ITGB3 (0.41) | NR1H2KDM4EPKMNAMPTESR2 | |
| SCHEMBL7286655 | 0.87 | NAMPT (0.42) | NR1H2KDM4EPKMNAMPTSIGMAR1 | |
| SCHEMBL7283282 | 0.86 | KDM4E (0.41) | NR1H2KDM4EPKMESR2SIGMAR1 | |
| SCHEMBL7275338 | 0.84 | ITGB3 (0.40) | NR1H2KDM4EPKMNAMPTSIGMAR1 | |
| SCHEMBL7281991 | 0.84 | KMT2A (0.36) | SIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528369-B1 | Cyclic imino derivatives, pharmaceutical compositions containing them and process for their preparation | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-11-24 | — | — | EP | disclosed |
| US-5455348-A | Anticoagulants | Thomae, Karl (DE) | 1995-10-03 | — | — | US | disclosed |
| EP-0528369-A2 | Cyclic imino derivatives, pharmaceutical compositions containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-02-24 | — | — | EP | disclosed |