Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7298559 | 0.93 | GABRP (0.38) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL7292065 | 0.82 | HTT (0.37) | MAPTALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL10559619 | 0.81 | GABRP (0.39) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL7289175 | 0.80 | MAPT (0.41) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL7286064 | 0.79 | MAPT (0.39) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL10570570 | 0.78 | KDM4E (0.37) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL7295183 | 0.77 | PDE4A (0.40) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL7286210 | 0.77 | GABRP (0.41) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL7297582 | 0.77 | MAPT (0.41) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL7379926 | 0.76 | MAPT (0.33) | MAPTALDH1A1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4849421-A | SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1989-07-18 | — | — | US | disclosed |
| EP-0281045-A1 | Benzothiepino (5,4-c) pyridazine compounds and their pharmaceutical uses | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1988-09-07 | — | — | EP | disclosed |