Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7289175 | 0.89 | MAPT (0.41) | KDM4EALDH1A1MEN1GAAMAPT | |
| SCHEMBL7289110 | 0.82 | KMT2A (0.40) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7379907 | 0.80 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7294604 | 0.79 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL10570570 | 0.79 | KDM4E (0.37) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7292065 | 0.79 | HTT (0.37) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7288041 | 0.77 | MAPT (0.34) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL10367572 | 0.77 | KDM4E (0.44) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7290530 | 0.76 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7297582 | 0.75 | MAPT (0.41) | KDM4EALDH1A1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281045-B1 | BENZOTHIEPINO (5,4-C) PYRIDAZINE COMPOUNDS AND THEIR PHARMACEUTICAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1991-12-27 | — | — | EP | disclosed |
| US-4849421-A | SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1989-07-18 | — | — | US | disclosed |
| EP-0281045-A1 | Benzothiepino (5,4-c) pyridazine compounds and their pharmaceutical uses | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1988-09-07 | — | — | EP | disclosed |