Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7288132 | 1.00 | HRH3 (0.49) | HRH3FFAR1MTNR1ACA2CA5A | |
| SCHEMBL7317620 | 0.85 | FFAR1 (0.54) | FFAR1CA2CA5ACYP3A4DRD2 | |
| SCHEMBL7317624 | 0.85 | FFAR1 (0.54) | FFAR1CA2CA5ACYP3A4DRD2 | |
| SCHEMBL4234794 | 0.84 | HRH3 (0.49) | HRH3FFAR1MTNR1ACA2CA5A | |
| SCHEMBL17761390 | 0.81 | HRH3 (0.44) | HRH3FFAR1MTNR1ACA2CA5A | |
| SCHEMBL177102 | 0.78 | CYP26A1 (0.47) | HRH3FFAR1CYP19A1 | |
| SCHEMBL15447319 | 0.78 | ELANE (0.43) | FFAR1MTNR1ACA2CA5A | |
| SCHEMBL177299 | 0.77 | FFAR1 (0.39) | HRH3FFAR1MTNR1ACYP3A4 | |
| SCHEMBL1870686 | 0.77 | MTNR1A (0.63) | FFAR1MTNR1A | |
| SCHEMBL11484008 | 0.77 | MTNR1A (0.56) | FFAR1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6359138-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. | 2002-03-19 | — | — | US | disclosed |
| EP-0846683-B1 | 4-Hydroxy-piperidine derivatives | HOFFMANN LA ROCHE (CH) | 2001-09-19 | — | — | EP | disclosed |
| EP-0846683-A1 | 4-Hydroxy-piperidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-06-10 | — | — | EP | disclosed |