Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29444764 | 0.94 | MTNR1A (0.63) | MTNR1AMAPTGAAFFAR1ALOX5 | |
| SCHEMBL1870686 | 0.94 | MTNR1A (0.63) | MTNR1AMAPTGAAFFAR1ALOX5 | |
| SCHEMBL6982719 | 0.94 | MTNR1A (0.63) | MTNR1AMAPTGAAFFAR1ALOX5 | |
| SCHEMBL28716707 | 0.83 | FFAR1 (0.54) | MTNR1AMAPTGAAFFAR1ALDH1A1 | |
| SCHEMBL28720097 | 0.83 | FFAR1 (0.54) | MTNR1AMAPTGAAFFAR1ALDH1A1 | |
| SCHEMBL11232203 | 0.82 | MTNR1A (0.57) | MTNR1AMAPTGAAFFAR1ALOX5 | |
| SCHEMBL9696456 | 0.81 | ALOX5 (0.65) | ALOX5ADRA1DADRA1AADRA1BADRB2 | |
| SCHEMBL8288367 | 0.80 | CA2 (0.51) | MTNR1AGAA | |
| SCHEMBL1107090 | 0.80 | CA2 (0.51) | MTNR1AGAA | |
| SCHEMBL1107087 | 0.80 | CA2 (0.51) | MTNR1AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4188390-A | Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines | PFIZER INC. (US) | 1980-02-12 | — | — | US | disclosed |