Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317620 | 1.00 | FFAR1 (0.54) | FFAR1HTR1AHTR1DHTR6CA2 | |
| SCHEMBL10508188 | 0.88 | HRH3 (0.50) | FFAR1DRD2DRD3 | |
| SCHEMBL7321911 | 0.87 | FFAR1 (0.52) | FFAR1HTR1AHTR1DHTR6CA2 | |
| SCHEMBL7316922 | 0.87 | FFAR1 (0.52) | FFAR1HTR1AHTR1DHTR6CA2 | |
| SCHEMBL7395858 | 0.85 | FFAR1 (0.51) | FFAR1HTR1AHTR1DHTR6CA2 | |
| SCHEMBL7288140 | 0.85 | HRH3 (0.49) | FFAR1HTR1AHTR1DCA2CA5A | |
| SCHEMBL7288132 | 0.85 | HRH3 (0.49) | FFAR1HTR1AHTR1DCA2CA5A | |
| SCHEMBL8036693 | 0.83 | FFAR1 (0.52) | FFAR1HTR1AHTR1DHTR6CA2 | |
| SCHEMBL8845097 | 0.81 | HTR6 (0.70) | HTR1AHTR1DHTR6 | |
| SCHEMBL10506130 | 0.80 | DRD2 (0.42) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684039-A | Chroman-2-ylmethylamino derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-11-04 | — | — | US | disclosed |
| US-5670667-A | DOPAMINE INHIBITORS FOR PSYCHOLOGICAL DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-23 | — | — | US | disclosed |
| US-5541199-A | DOPAMINE MODULATORS, SCHIZOPHRENIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-07-30 | — | — | US | disclosed |