Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 6/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7279018 | 0.82 | PDPK1 (0.41) | GPR35KDM4EALDH1A1GABRPGABRD | |
| SCHEMBL10578245 | 0.76 | TSHR (0.40) | TSHRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL16515634 | 0.75 | KDM4E (0.45) | GPR35TSHRKDM4EALDH1A1 | |
| SCHEMBL31400054 | 0.71 | PDPK1 (0.39) | KDM4EAKR1C3AKR1C2AKR1C1PTPN1 | |
| SCHEMBL31128943 | 0.69 | TSHR (0.37) | GPR35TSHRKDM4ECHEK1LIMK1 | |
| SCHEMBL4904323 | 0.69 | AKR1C3 (0.36) | GPR35TSHRKDM4EAKR1C4AKR1C3 | |
| SCHEMBL4543435 | 0.68 | GPR35 (0.41) | GPR35KDM4ECHEK1LIMK1DYRK1A | |
| SCHEMBL15053880 | 0.67 | EPRS1 (0.48) | KDM4EAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL15054611 | 0.67 | KDM4E (0.41) | TSHRKDM4EAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL2207338 | 0.67 | AKR1C3 (0.41) | TSHRKDM4EAKR1C4AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0560348-B1 | Thieno 3,2-b pyridine derivatives for the treatment of gastrointestinal disorders | MITSUBISHI CHEM CORP (JP) | 2002-07-10 | — | — | EP | disclosed |
| US-5352685-A | Gastrointestinal disorders | MITSUBISHI KASEI CORPORATION (JP) | 1994-10-04 | — | — | US | disclosed |
| EP-0560348-A1 | Thieno 3,2-b pyridine derivatives for the treatment of gastrointestinal disorders | Mitsubishi Chemical Corporation (JP) | 1993-09-15 | — | — | EP | disclosed |