Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.68 |
| ▸ | BACE1 | P56817 | 6/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | BCHE | P06276 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.59 |
| ▸ | CCR2 | P41597 | 1/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | ITK | Q08881 | 1/20 | 0.55 |
| ▸ | FAAH | O00519 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL918426 | 0.89 | KDM4E (0.66) | ACHEBACE1ALDH1A1BCHEROCK2 | |
| SCHEMBL7296842 | 0.87 | ACHE (0.60) | ACHEBACE1POLBALDH1A1LMNA | |
| SCHEMBL924357 | 0.87 | ACHE (0.68) | ACHEBACE1POLBALDH1A1LMNA | |
| SCHEMBL15919764 | 0.85 | SIGMAR1 (0.62) | ACHEBACE1ALDH1A1BCHEROCK2 | |
| SCHEMBL3997031 | 0.85 | ACHE (0.68) | ACHEBACE1ALDH1A1BCHEROCK2 | |
| SCHEMBL28331173 | 0.85 | KMT2A (0.67) | ACHEBACE1ALDH1A1LMNABCHE | |
| SCHEMBL23805141 | 0.85 | KMT2A (0.66) | POLBALDH1A1LMNABCHEROCK2 | |
| SCHEMBL7296818 | 0.85 | DCUN1D1 (0.69) | ACHEBACE1POLBALDH1A1LMNA | |
| SCHEMBL15920025 | 0.85 | ROCK2 (0.56) | ACHEBACE1POLBALDH1A1LMNA | |
| SCHEMBL7289534 | 0.85 | KMT2A (0.70) | ACHEBACE1ALDH1A1SMN1; SMN2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1036394-C | Process for preparing quinolone derivatives | OTSUKA PHARMA CO LTD (JP) | 1997-11-12 | — | — | CN | disclosed |
| US-5652247-A | VASOPRESSIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD (JP) | 1997-07-29 | — | — | US | disclosed |
| US-5436254-A | Vaopressin antagonists | OTSUKA PHARMACEUTICAL COMPANY, LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| US-5356904-A | Administering to prevent preterm labor in mammals | MERCK & CO., INC. (US) | 1994-10-18 | — | — | US | disclosed |
| EP-0382185-B1 | Carbostyril derivatives | OTSUKA PHARMA CO LTD (JP) | 1994-06-15 | — | — | EP | disclosed |
| US-5225402-A | Vasopressin antagonist, vasodilation, hypotensive, diuretics and anticoagulants | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-06 | — | — | US | disclosed |
| CN-1046529-A | Carbostyril derivative | OTSUKA PHARMA CO LTD (JP) | 1990-10-31 | — | — | CN | disclosed |
| EP-0382185-A2 | Carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |