Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7282372 | 0.89 | REN (0.43) | — | |
| SCHEMBL7278750 | 0.86 | CYP2C19 (0.36) | ALDH1A1MMP2MMP9MMP8 | |
| SCHEMBL7278600 | 0.83 | REN (0.41) | HPGDALDH1A1MMP2MMP9MMP8 | |
| SCHEMBL7281639 | 0.81 | REN (0.45) | KMT2AMEN1HPGDCTSDSMN1; SMN2 | |
| SCHEMBL7281155 | 0.81 | REN (0.45) | KMT2AMEN1HPGDCTSDSMN1; SMN2 | |
| SCHEMBL7288244 | 0.81 | REN (0.35) | MMP2 | |
| SCHEMBL7281421 | 0.80 | REN (0.38) | MMP2MMP9 | |
| SCHEMBL7281084 | 0.80 | REN (0.33) | MMP2 | |
| SCHEMBL7280966 | 0.79 | REN (0.35) | MMP2 | |
| SCHEMBL7288292 | 0.79 | REN (0.43) | KMT2AMEN1HPGDCTSDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589446-B1 | N-(Hydroxyethyl)butanediamide derivatives as renin inhibitors | BOEHRINGER INGELHEIM CA LTD (CA) | 1997-09-03 | — | — | EP | claimed |