Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.45 |
| ▸ | ERN1 | O75460 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | COMT | P21964 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287497 | 0.87 | MAPT (0.50) | MAPK1VCAM1ERN1MEN1KMT2A | |
| SCHEMBL3364760 | 0.86 | MAPK1 (0.64) | MAPK1VCAM1ERN1MAOBALDH1A1 | |
| SCHEMBL7391355 | 0.81 | MAPT (0.50) | MAPK1ERN1MEN1KMT2AMAOA | |
| SCHEMBL8943367 | 0.79 | MAPT (0.47) | MAPK1VCAM1MEN1KMT2ARAB9A | |
| SCHEMBL7390018 | 0.79 | ABCC3 (0.56) | MAPK1VCAM1MEN1KMT2ACOMT | |
| SCHEMBL7392802 | 0.79 | TTR (0.56) | MAPK1VCAM1ERN1ALDH1A1LMNA | |
| SCHEMBL29709767 | 0.77 | ERN1 (0.59) | VCAM1ERN1ALDH1A1MAPT | |
| SCHEMBL9022 | 0.77 | ERN1 (0.59) | VCAM1ERN1ALDH1A1MAPT | |
| SCHEMBL6694236 | 0.77 | ALDH1A1 (0.61) | VCAM1ERN1MEN1KMT2AMAOA | |
| SCHEMBL3053729 | 0.76 | CASP6 (0.66) | ERN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1030196-C | Positive inotropic and lusitropic 3,5-dihydro-imidazo [2,1-6] quinazolin-2(1H)-one derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-11-01 | — | — | CN | disclosed |
| EP-0406958-B1 | Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-03-15 | — | — | EP | disclosed |
| US-5220023-A | Intermediates for inotropic agents | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-06-15 | — | — | US | disclosed |
| US-5120845-A | Treating congestive heart failure | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-06-09 | — | — | US | disclosed |
| US-5043327-A | Treating mammals with congestive heart failure | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-27 | — | — | US | disclosed |
| CN-1051560-A | Contractile and relaxing force enhancing 3, 5-dihydroimidazo [2, 1-b ] quinazolin-2 (1H) -one derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1991-05-22 | — | — | CN | disclosed |
| EP-0406958-A2 | Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-09 | — | — | EP | disclosed |