Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ERN1 | O75460 | 4/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3364760 | 0.87 | MAPK1 (0.64) | MAPTMAPK1VCAM1ATMTDP1 | |
| SCHEMBL7390018 | 0.85 | ABCC3 (0.56) | TTRMAPTLMNAMAPK1VCAM1 | |
| SCHEMBL7287497 | 0.85 | MAPT (0.50) | TTRMAPTLMNAMAPK1VCAM1 | |
| SCHEMBL9583270 | 0.85 | TTR (0.59) | TTRMAPTLMNAMAPK1VCAM1 | |
| SCHEMBL564611 | 0.84 | ATM (0.60) | TTRMAPTLMNAVCAM1ATM | |
| SCHEMBL29547124 | 0.84 | ATM (0.60) | TTRMAPTLMNAVCAM1ATM | |
| SCHEMBL8943686 | 0.82 | MAPT (0.64) | MAPTLMNAMAPK1ERN1ALDH1A1 | |
| SCHEMBL3053729 | 0.80 | CASP6 (0.66) | LMNAERN1CASP6 | |
| SCHEMBL7288997 | 0.79 | MAPK1 (0.48) | MAPTLMNAMAPK1VCAM1ERN1 | |
| SCHEMBL7744242 | 0.79 | MAPK1 (0.75) | TTRMAPTLMNAMAPK1VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1041726-C | 1.3-Dihydro-2H-Imidazo{4,5-6} Quinolin-2-One derivatives. | JANSSEN PHARMACEUTICA NV (BE) | 1999-01-20 | — | — | CN | disclosed |
| US-5521187-A | PHOSPHODIESTERASE INHIBITORS, ANTIALLERGENS AND ATOPIC DISEASES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-05-28 | — | — | US | disclosed |
| US-5516908-A | ANTIALLERGENS, ATROPIC DISEASES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-05-14 | — | — | US | disclosed |
| EP-0610372-B1 | 1,3-DIHYDRO-2H-IMIDAZO(4,5-B)QUINOLIN-2-ONE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 1995-12-13 | — | — | EP | disclosed |
| EP-0610372-A1 | 1,3-DIHYDRO-2H-IMIDAZO(4,5-B)QUINOLIN-2-ONE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS. | JANSSEN PHARMACEUTICA NV (BE) | 1994-08-17 | — | — | EP | disclosed |
| WO-1993009118-A1 | 1,3-DIHYDRO-2H-IMIDAZO(4,5-B)QUINOLIN-2-ONE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-05-13 | — | — | WO | disclosed |
| EP-0541153-A1 | 1,3-Dihydro-2H-imidazo[4,5-b]-quinolin-2-one derivatives as phosphodiesterase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-05-12 | — | — | EP | disclosed |