Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 18/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL728787 | 1.00 | SLC6A4 (0.45) | SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL730450 | 1.00 | SLC6A4 (0.45) | SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL10001912 | 1.00 | SLC6A4 (0.45) | SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL4725048 | 1.00 | SLC6A4 (0.45) | SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL731894 | 1.00 | SLC6A4 (0.45) | SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL10001915 | 1.00 | SLC6A4 (0.45) | SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL4178896 | 0.87 | SLC6A4 (0.40) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL4181556 | 0.87 | SLC6A4 (0.40) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL4187460 | 0.87 | SLC6A3 (0.40) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL18346491 | 0.87 | SLC6A4 (0.37) | SLC6A4SLC6A3SLC6A2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170233333-A1 | PROCESS FOR THE SYNTHESIS OF (+) AND (-)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE | EUTHYMICS BIOSCIENCE, INC. | 2017-08-17 | — | — | US | disclosed |
| US-20170233333-A1 | PROCESS FOR THE SYNTHESIS OF (+) AND (-)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE | EUTHYMICS BIOSCIENCE, INC. | 2017-08-17 | — | — | US | disclosed |
| US-9527813-B2 | Process for the synthesis of (+) and (−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane | EUTHYMICS BIOSCIENCE, INC. (US) | 2016-12-27 | — | — | US | disclosed |
| US-9527813-B2 | Process for the synthesis of (+) and (−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane | EUTHYMICS BIOSCIENCE, INC. (US) | 2016-12-27 | — | — | US | disclosed |
| US-20140163240-A1 | PROCESS FOR THE SYNTHESIS OF (+) AND (-)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE | ETHISMOS RESEARCH, INC. | 2014-06-12 | — | — | US | disclosed |
| US-20140163240-A1 | PROCESS FOR THE SYNTHESIS OF (+) AND (-)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE | ETHISMOS RESEARCH, INC. | 2014-06-12 | — | — | US | disclosed |
| US-20120142940-A1 | Process For The Synthesis Of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicycle[3.1.0]Hexane | ETHISMOS RESEARCH, INC. | 2012-06-07 | — | — | US | disclosed |
| US-20120142940-A1 | Process For The Synthesis Of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicycle[3.1.0]Hexane | ETHISMOS RESEARCH, INC. | 2012-06-07 | — | — | US | disclosed |
| US-8138377-B2 | Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use | DOV PHARMACEUTICAL, INC. (US) | 2012-03-20 | — | — | US | disclosed |
| US-8138377-B2 | Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use | DOV PHARMACEUTICAL, INC. (US) | 2012-03-20 | — | — | US | disclosed |
| US-20080194696-A1 | Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use | ETHISMOS RESEARCH, INC. | 2008-08-14 | — | — | US | disclosed |
| US-20080194696-A1 | Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use | ETHISMOS RESEARCH, INC. | 2008-08-14 | — | — | US | disclosed |
| WO-2008057575-A2 | NOVEL ARYLBICYCLO[3.1.0]HEXYLAMINES AND METHODS AND COMPOSITIONS FOR THEIR PREPARATION AND USE | DOV PHARMACEUTICAL, INC. (US) | 2008-05-15 | — | — | WO | disclosed |
| US-20080058535-A1 | METHODS AND COMPOSITIONS FOR PRODUCTION, FORMULATION AND USE OF 1 ARYL-3-AZABICYCLO[3.1.0]HEXANES | DOV PHARMACEUTICAL, INC. | 2008-03-06 | — | — | US | disclosed |
| US-20080058535-A1 | METHODS AND COMPOSITIONS FOR PRODUCTION, FORMULATION AND USE OF 1 ARYL-3-AZABICYCLO[3.1.0]HEXANES | DOV PHARMACEUTICAL, INC. | 2008-03-06 | — | — | US | disclosed |
| US-20080058535-A1 | METHODS AND COMPOSITIONS FOR PRODUCTION, FORMULATION AND USE OF 1 ARYL-3-AZABICYCLO[3.1.0]HEXANES | DOV PHARMACEUTICAL, INC. | 2008-03-06 | — | — | US | disclosed |
| US-20080045725-A1 | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane | ETHISMOS RESEARCH, INC. | 2008-02-21 | — | — | US | disclosed |
| US-20080045725-A1 | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane | ETHISMOS RESEARCH, INC. | 2008-02-21 | — | — | US | disclosed |
| WO-2008013856-A2 | METHODS AND COMPOSITIONS FOR PRODUCTION, FORMULATION AND USE OF 1 ARYL -3-AZABICYCLO[3.1.0 ] HEXANES | DOV PHARMACEUTICAL, INC. (US) | 2008-01-31 | — | — | WO | disclosed |
| WO-2007127396-A1 | PROCESS FOR THE SYNTHESIS OF (+) AND (-) -1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE | DOV PHARMACEUTICAL, INC. (US) | 2007-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045725-A1 | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane | ADH1C, DDT, UROD | SLC6A4 178/4885SLC6A3 33/4885SLC6A2 185/4885 |
| US-20080194696-A1 | Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use | HTR2C, HTR1B, HTR3C | SLC6A4 93/4885SLC6A3 76/4885SLC6A2 150/4885 |
| US-20080058535-A1 | METHODS AND COMPOSITIONS FOR PRODUCTION, FORMULATION AND USE OF 1 ARYL-3-AZABICYCLO[3.1.0]HEXANES | CYP1B1, CYP2B6, CYP2D6 | SLC6A4 2230/4885SLC6A3 982/4885SLC6A2 3023/4885 |
| US-20120142940-A1 | Process For The Synthesis Of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicycle[3.1.0]Hexane | ADH1C, DDT, UROD | SLC6A4 226/4885SLC6A3 36/4885SLC6A2 211/4885 |
| US-20170233333-A1 | PROCESS FOR THE SYNTHESIS OF (+) AND (-)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE | ADH1C, DDT, UROD | SLC6A4 178/4885SLC6A3 33/4885SLC6A2 185/4885 |
| US-20140163240-A1 | PROCESS FOR THE SYNTHESIS OF (+) AND (-)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE | ADH1C, DDT, UROD | SLC6A4 178/4885SLC6A3 33/4885SLC6A2 185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.