Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295144 | 0.84 | HTR2A (0.51) | DRD2DRD4HTR2AHTR2CHRH1 | |
| Hydrochloric Acid SCHEMBL7338534 | 0.83 | HTR2A (0.50) | DRD2DRD4HTR2AHTR2CHRH1 | |
| SCHEMBL445421 | 0.75 | DRD2 (0.69) | DRD2DRD4 | |
| SCHEMBL7297531 | 0.73 | TSHR (0.38) | — | |
| SCHEMBL11805096 | 0.72 | HTR2C (0.59) | SLC6A4HTR2AHTR2C | |
| SCHEMBL9442839 | 0.72 | HTR2C (0.41) | SLC6A4HTR2AHTR2C | |
| Water SCHEMBL466845 | 0.72 | HTR2A (0.45) | DRD2DRD4HTR2AHTR2CHRH1 | |
| Hydrochloric Acid SCHEMBL11806534 | 0.70 | HTR2C (0.61) | SLC6A4HTR2AHTR2C | |
| SCHEMBL11809204 | 0.69 | HTR2C (0.46) | SLC6A4HTR2AHTR2CHRH1 | |
| SCHEMBL6615099 | 0.69 | SLC6A4 (0.59) | SLC6A4LMNADRD2DRD4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0455195-B1 | Ethanobicyclic amine derivatives for CNS disorders | SEARLE & CO (US) | 1997-10-22 | — | — | EP | claimed |
| US-5089506-A | Antipsychotic agents, anticonvulsants | G. D. SEARLE & CO. (US) | 1992-02-18 | — | — | US | claimed |
| EP-0455195-A2 | Ethanobicyclic amine derivatives for CNS disorders | G.D. Searle & Co. (US) | 1991-11-06 | — | — | EP | claimed |
| EP-0455195-B1 | Ethanobicyclic amine derivatives for CNS disorders | SEARLE & CO (US) | 1997-10-22 | — | — | EP | disclosed |
| US-5215992-A | Treating psychotic, convulsive, dystonic disorders, cerebral ischemia | G. D. SEARLE & CO. (US) | 1993-06-01 | — | — | US | disclosed |
| US-5089506-A | Antipsychotic agents, anticonvulsants | G. D. SEARLE & CO. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0455195-A2 | Ethanobicyclic amine derivatives for CNS disorders | G.D. Searle & Co. (US) | 1991-11-06 | — | — | EP | disclosed |