Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.51 |
| ▸ | HTR2C | P28335 | 3/20 | 0.51 |
| ▸ | HRH1 | P35367 | 3/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 13/20 | 0.42 |
| ▸ | DRD4 | P21917 | 11/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7338534 | 0.98 | HTR2A (0.50) | HTR2AHTR2CHRH1ACHEDRD2 | |
| Water SCHEMBL466845 | 0.87 | HTR2A (0.45) | HTR2AHTR2CHRH1ACHEDRD2 | |
| SCHEMBL7290101 | 0.84 | SLC6A4 (0.46) | HTR2AHTR2CHRH1DRD2DRD4 | |
| SCHEMBL22335162 | 0.76 | DRD2 (0.69) | DRD2DRD4 | |
| SCHEMBL19262539 | 0.76 | DRD2 (0.69) | DRD2DRD4 | |
| SCHEMBL7290235 | 0.74 | MCOLN2 (0.38) | HTR2AHTR2CHRH1 | |
| SCHEMBL9442839 | 0.73 | HTR2C (0.41) | HTR2AHTR2C | |
| SCHEMBL11805096 | 0.70 | HTR2C (0.59) | HTR2AHTR2C | |
| SCHEMBL11226929 | 0.69 | SLC6A4 (0.59) | HTR2AHTR2CHRH1DRD2 | |
| SCHEMBL9442852 | 0.69 | OPRM1 (0.42) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0455195-B1 | Ethanobicyclic amine derivatives for CNS disorders | SEARLE & CO (US) | 1997-10-22 | — | — | EP | claimed |
| US-5215992-A | Treating psychotic, convulsive, dystonic disorders, cerebral ischemia | G. D. SEARLE & CO. (US) | 1993-06-01 | — | — | US | claimed |
| EP-0455195-A2 | Ethanobicyclic amine derivatives for CNS disorders | G.D. Searle & Co. (US) | 1991-11-06 | — | — | EP | claimed |
| EP-0455195-B1 | Ethanobicyclic amine derivatives for CNS disorders | SEARLE & CO (US) | 1997-10-22 | — | — | EP | disclosed |
| US-5215992-A | Treating psychotic, convulsive, dystonic disorders, cerebral ischemia | G. D. SEARLE & CO. (US) | 1993-06-01 | — | — | US | disclosed |
| US-5089506-A | Antipsychotic agents, anticonvulsants | G. D. SEARLE & CO. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0455195-A2 | Ethanobicyclic amine derivatives for CNS disorders | G.D. Searle & Co. (US) | 1991-11-06 | — | — | EP | disclosed |