Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.38 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297531 | 0.82 | TSHR (0.38) | — | |
| SCHEMBL7295144 | 0.74 | HTR2A (0.51) | HTR2AHTR2CHRH1 | |
| Hydrochloric Acid SCHEMBL7338534 | 0.73 | HTR2A (0.50) | HTR2AHTR2CHRH1 | |
| Water SCHEMBL466846 | 0.68 | SIGMAR1 (0.40) | MCOLN2MCOLN1HTR2AHTR2CHRH1 | |
| SCHEMBL28325127 | 0.68 | SLC9A3 (0.41) | HTR2CHRH1SIGMAR1 | |
| SCHEMBL9772314 | 0.66 | ADRA2A (0.41) | MCOLN2MCOLN1HTR2AHTR2CHRH1 | |
| SCHEMBL7951592 | 0.66 | ADRA2A (0.41) | MCOLN2MCOLN1HTR2AHTR2CHRH1 | |
| SCHEMBL13503895 | 0.66 | PRCP (0.54) | — | |
| SCHEMBL8245892 | 0.66 | HTR2A (0.51) | HTR2AHTR2CHRH1HTR7 | |
| Water SCHEMBL466845 | 0.65 | HTR2A (0.45) | HTR2AHTR2CHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0455195-B1 | Ethanobicyclic amine derivatives for CNS disorders | SEARLE & CO (US) | 1997-10-22 | — | — | EP | claimed |
| US-5215992-A | Treating psychotic, convulsive, dystonic disorders, cerebral ischemia | G. D. SEARLE & CO. (US) | 1993-06-01 | — | — | US | claimed |
| EP-0455195-A2 | Ethanobicyclic amine derivatives for CNS disorders | G.D. Searle & Co. (US) | 1991-11-06 | — | — | EP | claimed |
| EP-0455195-B1 | Ethanobicyclic amine derivatives for CNS disorders | SEARLE & CO (US) | 1997-10-22 | — | — | EP | disclosed |
| US-5215992-A | Treating psychotic, convulsive, dystonic disorders, cerebral ischemia | G. D. SEARLE & CO. (US) | 1993-06-01 | — | — | US | disclosed |
| US-5089506-A | Antipsychotic agents, anticonvulsants | G. D. SEARLE & CO. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0455195-A2 | Ethanobicyclic amine derivatives for CNS disorders | G.D. Searle & Co. (US) | 1991-11-06 | — | — | EP | disclosed |