Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | UBE2N | P61088 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7288882 | 0.90 | ADRA2C (0.69) | KMT2AADRA2CACHEHTTALDH1A1 | |
| SCHEMBL294596 | 0.78 | SMN1; SMN2 (0.49) | KDM4EKMT2AADRA2CHTTALDH1A1 | |
| SCHEMBL9735019 | 0.77 | NPY2R (0.62) | KDM4EKMT2AACHEL3MBTL1MAPT | |
| SCHEMBL4483065 | 0.77 | MLYCD (0.46) | KDM4EKMT2AADRA2CACHEPDE10A | |
| SCHEMBL18358943 | 0.77 | HRH3 (0.48) | KDM4EKMT2AADRA2CACHEALDH1A1 | |
| SCHEMBL23406121 | 0.77 | TSHR (0.46) | KMT2AADRA2CHTTTSHRMEN1 | |
| SCHEMBL29743815 | 0.77 | TSHR (0.46) | KMT2AADRA2CHTTTSHRMEN1 | |
| SCHEMBL3060251 | 0.76 | TSHR (0.71) | KDM4EKMT2AACHEHTTALDH1A1 | |
| SCHEMBL23405966 | 0.76 | TSHR (0.45) | KMT2AADRA2CTSHRMEN1NPC1 | |
| SCHEMBL29743800 | 0.76 | TSHR (0.45) | KMT2AADRA2CTSHRMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0453658-A2 | Use of substituted anilides and sulfonamides in the treatment of cardiovascular diseases | E.R. SQUIBB & SONS, INC. (US) | 1991-10-30 | — | — | EP | claimed |
| EP-0453658-A2 | Use of substituted anilides and sulfonamides in the treatment of cardiovascular diseases | E.R. SQUIBB & SONS, INC. (US) | 1991-10-30 | — | — | EP | disclosed |