Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 13/20 | 0.55 |
| ▸ | MMP1 | P03956 | 11/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 5/20 | 0.43 |
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7204063 | 0.89 | MMP13 (0.53) | MMP13MMP1ADAMTS4MMP2MMP9 | |
| SCHEMBL7201008 | 0.88 | MMP13 (0.54) | MMP13MMP1ADAMTS4MMP2MMP9 | |
| SCHEMBL7202562 | 0.88 | MMP13 (0.55) | MMP13MMP1ADAMTS4MMP2MMP9 | |
| Hydroxyamine SCHEMBL7209949 | 0.87 | MMP13 (0.42) | MMP13MMP1MMP2MMP9RORC | |
| SCHEMBL7199642 | 0.85 | MMP13 (0.57) | MMP13MMP1ADAMTS4MMP2MMP9 | |
| SCHEMBL7201763 | 0.85 | MMP13 (0.55) | MMP13MMP1ADAMTS4MMP2MMP9 | |
| SCHEMBL7209957 | 0.85 | MMP13 (0.41) | MMP13MMP1MMP2MMP9RORC | |
| SCHEMBL7207000 | 0.83 | MMP13 (0.79) | MMP13MMP1ADAMTS4MMP2MMP9 | |
| SCHEMBL7201536 | 0.83 | MMP13 (0.53) | MMP13MMP1ADAMTS4MMP2MMP9 | |
| SCHEMBL7300731 | 0.83 | MMP13 (0.67) | MMP13MMP1ADAMTS4MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1138680-A1 | Gem substituted sulfonyl hydroxamic acids as MMP inhibitors | Pfizer Products Inc. (US) | 2001-10-04 | — | — | EP | disclosed |