Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.53 |
| ▸ | ACE | P12821 | 2/20 | 0.53 |
| ▸ | CPA1 | P15085 | 1/20 | 0.53 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 3/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7265320 | 0.84 | OPRK1 (0.58) | MMEACECPA1ACE2MMP9 | |
| SCHEMBL3660997 | 0.83 | MME (0.59) | MMEACECPA1ACE2MMP9 | |
| SCHEMBL8668232 | 0.83 | MME (0.59) | MMEACECPA1ACE2MMP9 | |
| SCHEMBL3658383 | 0.82 | MME (0.58) | MMEACECPA1ACE2MMP9 | |
| SCHEMBL8673998 | 0.82 | MME (0.58) | MMEACECPA1ACE2MMP9 | |
| SCHEMBL8668240 | 0.82 | MME (0.62) | MMEACECPA1ACE2MMP9 | |
| SCHEMBL3660841 | 0.82 | MME (0.62) | MMEACECPA1ACE2MMP9 | |
| SCHEMBL3660699 | 0.81 | FAAH (0.58) | MMEACECPA1ACE2HRH4 | |
| SCHEMBL3663736 | 0.81 | FAAH (0.58) | MMEACECPA1ACE2HRH4 | |
| SCHEMBL3658643 | 0.81 | FAAH (0.58) | MMEACECPA1ACE2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0274259-A2 | New renin-inhibitory oligopeptides, their preparaton and their use | Sankyo Company Limited (JP) | 1988-07-13 | — | — | EP | disclosed |