Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC3 | O15438 | 1/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | RARB | P10826 | 1/20 | 0.48 |
| ▸ | COMT | P21964 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | KLF10 | Q13118 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7290618 | 0.90 | MAPK1 (0.56) | KMT2AALDH1A1MAPK1MEN1POLB | |
| SCHEMBL6780022 | 0.87 | TSHR (0.47) | ALDH1A1MAPTTSHRTDP1 | |
| SCHEMBL7288107 | 0.86 | TSHR (0.39) | ABCC3ABCC4NR1I2ABCB11TTR | |
| SCHEMBL7288114 | 0.86 | TSHR (0.39) | ABCC3ABCC4NR1I2ABCB11TTR | |
| SCHEMBL7288096 | 0.86 | TSHR (0.39) | ABCC3ABCC4NR1I2ABCB11TTR | |
| SCHEMBL9584460 | 0.86 | LMNA (0.49) | ABCC3ABCC4NR1I2ABCB11TTR | |
| SCHEMBL7299152 | 0.82 | MAPK1 (0.44) | KMT2ALMNAALDH1A1MAPK1HTT | |
| SCHEMBL9585074 | 0.81 | LMNA (0.48) | KMT2ALMNAALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL7297457 | 0.81 | MAPK1 (0.56) | KMT2ALMNAALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL7289769 | 0.80 | ALDH1A1 (0.43) | KMT2ALMNAALDH1A1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0406958-B1 | Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-03-15 | — | — | EP | disclosed |
| EP-0406958-A2 | Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-09 | — | — | EP | disclosed |