Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 14/20 | 0.65 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9844330 | 0.90 | OPRL1 (0.54) | SIGMAR1OPRM1OPRD1OPRL1GRM2 | |
| SCHEMBL7290651 | 0.88 | SIGMAR1 (0.83) | SIGMAR1 | |
| SCHEMBL7299765 | 0.88 | SIGMAR1 (0.68) | SIGMAR1GRM2 | |
| SCHEMBL9844063 | 0.88 | SIGMAR1 (0.54) | SIGMAR1OPRM1OPRD1OPRL1GRM2 | |
| SCHEMBL9844060 | 0.87 | OPRM1 (0.53) | SIGMAR1OPRM1OPRD1OPRL1GRM2 | |
| SCHEMBL9844475 | 0.87 | SIGMAR1 (0.53) | SIGMAR1OPRM1OPRD1OPRL1GRM2 | |
| SCHEMBL7291646 | 0.86 | SIGMAR1 (0.71) | SIGMAR1GRM2 | |
| SCHEMBL9844429 | 0.86 | OPRL1 (0.58) | SIGMAR1OPRM1OPRD1OPRL1GRM2 | |
| SCHEMBL7301444 | 0.85 | SIGMAR1 (0.83) | SIGMAR1 | |
| SCHEMBL9844125 | 0.85 | SIGMAR1 (0.61) | SIGMAR1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459256-B1 | Oxazolidinones with CNS-depressant activity | MERCK PATENT GMBH (DE) | 1995-07-12 | — | — | EP | disclosed |
| US-5232931-A | OXAZOLIDINONES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-08-03 | — | — | US | disclosed |
| EP-0459256-A1 | Oxazolidinones with CNS-depressant activity | MERCK PATENT GmbH (DE) | 1991-12-04 | — | — | EP | disclosed |