SCHEMBL7301444

SCHEMBL7301444

O=C1OC(CCN2CCC(O)(c3ccc4c(c3)OCO4)CC2)CN1c1ccc(F)cc1

nearest known ligand 0.83

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 18/20 0.83
LMNA P02545 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7290999 0.91 SIGMAR1 (0.83) SIGMAR1
SCHEMBL7300487 0.91 SIGMAR1 (1.00) SIGMAR1
SCHEMBL7290651 0.91 SIGMAR1 (0.83) SIGMAR1
SCHEMBL7300001 0.91 SIGMAR1 (1.00) SIGMAR1
Hydrochloric Acid SCHEMBL7300654 0.90 SIGMAR1 (0.98) SIGMAR1
SCHEMBL7291705 0.89 SIGMAR1 (0.84) SIGMAR1
SCHEMBL9844272 0.89 SIGMAR1 (0.69) SIGMAR1
SCHEMBL7299765 0.85 SIGMAR1 (0.68) SIGMAR1
SCHEMBL7290707 0.85 SIGMAR1 (0.65) SIGMAR1
SCHEMBL9844323 0.84 SIGMAR1 (0.64) SIGMAR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0459256-B1 Oxazolidinones with CNS-depressant activity MERCK PATENT GMBH (DE) 1995-07-12 EP disclosed
US-5232931-A OXAZOLIDINONES MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1993-08-03 US disclosed
EP-0459256-A1 Oxazolidinones with CNS-depressant activity MERCK PATENT GmbH (DE) 1991-12-04 EP disclosed