Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | ITGAL | P20701 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CRHBP | P24387 | 2/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 2/20 | 0.31 |
| ▸ | PKLR | P30613 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7290581 | 0.77 | ITGB2 (0.38) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL9584137 | 0.77 | MAP3K14 (0.43) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL7294185 | 0.77 | ITGB2 (0.38) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL7302180 | 0.77 | ITGB2 (0.34) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL9583523 | 0.73 | CTNNB1 (0.43) | ITGB2ICAM1ITGALLMNANPC1 | |
| SCHEMBL7300190 | 0.73 | TRPA1 (0.36) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL7293468 | 0.73 | ITGB2 (0.31) | ITGB2ICAM1ITGAL | |
| SCHEMBL7299199 | 0.69 | ADRA2A (0.33) | — | |
| SCHEMBL1450831 | 0.67 | ITGB2 (0.50) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL433176 | 0.67 | ITGB2 (0.50) | ITGB2ICAM1ITGALSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260444-A | Cardiovascular, hypotensive | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1993-11-09 | — | — | US | disclosed |
| US-5208245-A | Hypotensive agents | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1993-05-04 | — | — | US | disclosed |
| EP-0460418-A2 | Novel Dihydropyridine derivative | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1991-12-11 | — | — | EP | disclosed |