Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 9/20 | 0.47 |
| ▸ | CTSS | P25774 | 5/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430078 | 1.00 | REN (0.47) | RENCTSSMMP2MMP9MMP8 | |
| SCHEMBL7283916 | 0.82 | REN (0.48) | RENCTSSMMP2MMP9MMP8 | |
| SCHEMBL7283907 | 0.82 | REN (0.48) | RENCTSSMMP2MMP9MMP8 | |
| SCHEMBL13840602 | 0.80 | REN (0.48) | RENMMP2MMP9MMP8 | |
| SCHEMBL11981992 | 0.80 | REN (0.48) | RENMMP2MMP9MMP8 | |
| SCHEMBL10572007 | 0.79 | REN (0.59) | RENCTSSMMP2MMP9MMP8 | |
| SCHEMBL22546510 | 0.78 | KMT2A (0.46) | RENMMP2MMP9MMP8 | |
| SCHEMBL21706328 | 0.78 | REN (0.44) | RENMMP2MMP9MMP8 | |
| SCHEMBL13839332 | 0.77 | REN (0.48) | RENMMP2MMP9MMP8 | |
| SCHEMBL9852728 | 0.77 | KDM4E (0.53) | CTSSMMP2MMP9MMP8CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0264106-B1 | 5-Substituted amino-4-hydroxy-pentanoic acid derivatives and their use | BANYU PHARMA CO LTD (JP) | 1994-03-16 | — | — | EP | disclosed |
| US-4851387-A | RENIN INHIBITORS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1989-07-25 | — | — | US | disclosed |
| EP-0264106-A2 | 5-Substituted amino-4-hydroxy-pentanoic acid derivatives and their use | Banyu Pharmaceutical Co., Ltd. (JP) | 1988-04-20 | — | — | EP | disclosed |