Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 8/20 | 0.45 |
| ▸ | CTSS | P25774 | 8/20 | 0.45 |
| ▸ | CTSL | P07711 | 5/20 | 0.45 |
| ▸ | CTSK | P43235 | 5/20 | 0.45 |
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7277116 | 0.87 | CTSS (0.45) | CTSBCTSSCTSLCTSKTACR1 | |
| SCHEMBL7268195 | 0.83 | CTSL (0.63) | CTSBCTSSCTSLCTSKTACR1 | |
| SCHEMBL7294146 | 0.81 | CTSL (0.44) | CTSBCTSSCTSLCTSKTACR1 | |
| SCHEMBL7292590 | 0.77 | TACR1 (0.46) | CTSBCTSSCTSLCTSKTACR1 | |
| SCHEMBL7285600 | 0.76 | CTSL (0.46) | CTSBCTSSCTSLCTSKPSMB5 | |
| SCHEMBL7285846 | 0.75 | CTSL (0.44) | CTSBCTSSCTSLCTSKTACR1 | |
| SCHEMBL7268325 | 0.70 | CTSL (0.60) | CTSBCTSSCTSLCTSKTACR1 | |
| SCHEMBL7275048 | 0.70 | TACR1 (0.65) | CTSBCTSSCTSLCTSKTACR1 | |
| SCHEMBL23115576 | 0.68 | PSMB5 (0.59) | CTSSCTSKPSMB5MMEACE | |
| SCHEMBL7287953 | 0.67 | KDM4E (0.40) | CTSBCTSSCTSLCTSKTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376012-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |