Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300716 | 0.94 | MEN1 (0.50) | SIRT6LMNAMEN1KMT2AMAPT | |
| Fumaric Acid SCHEMBL9311250 | 0.91 | MAPT (0.47) | SIRT6LMNAMEN1KMT2AMAPT | |
| Fumaric Acid SCHEMBL9311256 | 0.91 | MAPT (0.47) | SIRT6LMNAMEN1KMT2AMAPT | |
| SCHEMBL29045758 | 0.85 | MEN1 (0.55) | SIRT6LMNAMEN1KMT2AMAPT | |
| SCHEMBL3088232 | 0.83 | PYCR1 (0.51) | LMNAMAPTHRH3ALDH1A1PYCR1 | |
| SCHEMBL9451699 | 0.82 | SIRT6 (0.51) | SIRT6LMNAMEN1KMT2AMAPT | |
| SCHEMBL3440277 | 0.81 | MEN1 (0.56) | SIRT6LMNAMEN1KMT2AMAPT | |
| SCHEMBL9310257 | 0.80 | MAPT (0.46) | LMNAMEN1KMT2AMAPTHRH3 | |
| SCHEMBL11776717 | 0.80 | KCNH2 (0.54) | MEN1KMT2AALDH1A1PYCR1 | |
| SCHEMBL25108483 | 0.79 | CHKA (0.50) | KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0503411-B1 | Substituted N-phenylpiperidines and medicaments thereof | BASF AG (DE) | 1995-11-29 | — | — | EP | disclosed |
| US-5296485-A | Substituted N-phenylpiperidines and drugs therefrom | BASF AKTIENGESELLSCHAFT (DE) | 1994-03-22 | — | — | US | disclosed |
| EP-0503411-A1 | Substituted N-phenylpiperidines and medicaments thereof | BASF Aktiengesellschaft (DE) | 1992-09-16 | — | — | EP | disclosed |