Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
| ▸ | AGXT | P21549 | 2/20 | 0.43 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1748464 | 0.79 | LTA4H (0.46) | HTTMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL7790214 | 0.76 | HAO1 (0.47) | HTTMEN1KMT2AMAPTLMNA | |
| SCHEMBL7294631 | 0.74 | ALDH1A1 (0.46) | HTTMEN1KMT2AMAPTLMNA | |
| SCHEMBL29366638 | 0.73 | CYP1A2 (0.64) | ENPP3ALPLENPP1XIAPHTT | |
| SCHEMBL395026 | 0.73 | CYP1A2 (0.64) | ENPP3ALPLENPP1XIAPHTT | |
| SCHEMBL8323293 | 0.72 | CA12 (0.50) | ENPP1MEN1KMT2AMAPTLMNA | |
| SCHEMBL1748605 | 0.72 | ALDH1A1 (0.56) | MEN1KMT2AMAPTLMNACYP1A2 | |
| SCHEMBL11292862 | 0.71 | HTT (0.53) | ENPP3ALPLENPP1XIAPHTT | |
| SCHEMBL29378143 | 0.71 | CYP1A2 (0.61) | ENPP3ALPLENPP1XIAPHTT | |
| Hydrochloric Acid SCHEMBL9443225 | 0.71 | CYP1A2 (0.61) | ENPP3ALPLENPP1XIAPHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |