Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | REN | P00797 | 14/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | CTSE | P14091 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293407 | 0.86 | CTSS (0.39) | CTSSCTSKRENCACNA1BCTSD | |
| SCHEMBL7280909 | 0.85 | CTSS (0.40) | CTSSCTSKRENCACNA1BCTSD | |
| SCHEMBL7281024 | 0.85 | CTSS (0.40) | CTSSCTSKRENCACNA1BCTSD | |
| SCHEMBL7281111 | 0.85 | CTSK (0.48) | CTSSCTSKRENCACNA1BCTSD | |
| SCHEMBL7291461 | 0.84 | CTSS (0.43) | CTSSCTSKRENCACNA1BCTSD | |
| SCHEMBL10592277 | 0.84 | CTSS (0.41) | CTSSCTSKRENCACNA1BCTSD | |
| SCHEMBL7299478 | 0.84 | CTSS (0.41) | CTSSCTSKRENCACNA1BCTSD | |
| SCHEMBL7298823 | 0.81 | CTSS (0.36) | CTSSCTSKRENCACNA1BCTSD | |
| SCHEMBL7293395 | 0.80 | CTSS (0.39) | CTSSCTSKRENCACNA1BCTSD | |
| SCHEMBL7293382 | 0.79 | REN (0.37) | CTSSCTSKRENCTSDCTSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5268374-A | Containing both amide and hydroxy groups | ABBOTT LABORATORIES (US) | 1993-12-07 | — | — | US | disclosed |
| EP-0437508-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-07-24 | — | — | EP | disclosed |
| WO-1990003971-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-04-19 | — | — | WO | disclosed |
| WO-1989010751-A1 | FUNCTIONALIZED PEPTIDYL AMINODIOLS AND -TRIOLS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |
| EP-0341602-A2 | Renin-inhibiting functionalized peptidyl aminodiols and - triols | ABBOTT LABORATORIES (US) | 1989-11-15 | — | — | EP | disclosed |