Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 4/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 7/20 | 0.34 |
| ▸ | TYR | P14679 | 2/20 | 0.34 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807547 | 0.82 | RXRA (0.44) | POLA1CYP19A1ERN1TYRTRIM24 | |
| SCHEMBL22477463 | 0.80 | ALDH1A1 (0.46) | POLA1ESR1ESR2ALDH1A1MAPT | |
| SCHEMBL8678472 | 0.80 | ALDH1A1 (0.46) | POLA1ESR1ESR2ALDH1A1MAPT | |
| SCHEMBL7295409 | 0.78 | ALDH1A1 (0.49) | POLA1ESR1ALDH1A1MAPTTDP1 | |
| SCHEMBL10323390 | 0.75 | RXRA (0.40) | CYP19A1ESR1ESR2ALDH1A1MAPT | |
| SCHEMBL1496263 | 0.74 | FTO (0.43) | CYP19A1ESR1ESR2ALDH1A1MAPT | |
| SCHEMBL1496245 | 0.74 | CYP19A1 (0.38) | POLA1CYP19A1ESR1ESR2ALDH1A1 | |
| SCHEMBL1496260 | 0.74 | CYP19A1 (0.39) | CYP19A1ESR1ESR2ALDH1A1MAPT | |
| SCHEMBL11340266 | 0.73 | RXRA (0.43) | ALDH1A1MAPTRECQLTDP1KDM4E | |
| SCHEMBL22589962 | 0.73 | ESR1 (0.35) | ESR1ESR2ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4980352-A | HYPOTENSIVE AGENTS; POTASSIUM-CONSERVING | ICI AMERICAS INC. (US) | 1990-12-25 | — | — | US | disclosed |
| EP-0343865-A1 | Bicyclic compounds | ICI AMERICAS INC. (US) | 1989-11-29 | — | — | EP | disclosed |