Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.91 |
| ▸ | MME | P08473 | 3/20 | 0.91 |
| ▸ | ECE1 | P42892 | 3/20 | 0.91 |
| ▸ | NPPA | P01160 | 1/20 | 0.91 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | CHRND | Q07001 | 6/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.38 |
| ▸ | CHRNG | P07510 | 2/20 | 0.38 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | NPY4R | P50391 | 3/20 | 0.38 |
| ▸ | NPY1R | P25929 | 2/20 | 0.38 |
| ▸ | NPY2R | P49146 | 2/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sampatrilat SCHEMBL7301333 | 0.95 | ECE1 (1.00) | ACEMMEECE1NPPAITGB3 | |
| Sampatrilat SCHEMBL49066 | 0.95 | ECE1 (1.00) | ACEMMEECE1NPPAITGB3 | |
| Sampatrilat SCHEMBL4567110 | 0.95 | ECE1 (1.00) | ACEMMEECE1NPPAITGB3 | |
| SCHEMBL7294361 | 0.88 | MME (0.80) | ACEMMEECE1NPPAITGB3 | |
| SCHEMBL7302883 | 0.85 | MME (0.82) | ACEMMEECE1NPPAITGB3 | |
| SCHEMBL7302871 | 0.85 | MME (0.82) | ACEMMEECE1NPPAITGB3 | |
| SCHEMBL9755065 | 0.85 | MME (0.81) | ACEMMEECE1NPPAMMP1 | |
| SCHEMBL9755064 | 0.85 | MME (0.81) | ACEMMEECE1NPPAMMP1 | |
| SCHEMBL6441043 | 0.85 | ACE (0.81) | ACEMMEECE1NPPAITGB3 | |
| SCHEMBL7322697 | 0.83 | ECE1 (0.77) | ACEMMEECE1NPPAITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358398-A1 | Cycloalkyl-substituted glutaramide antihypertensive agents | Pfizer Limited (GB) | 1990-03-14 | — | — | EP | disclosed |