Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 4/20 | 0.81 |
| ▸ | ECE1 | P42892 | 4/20 | 0.81 |
| ▸ | ACE | P12821 | 3/20 | 0.81 |
| ▸ | NPPA | P01160 | 1/20 | 0.81 |
| ▸ | ITGB1 | P05556 | 7/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 7/20 | 0.45 |
| ▸ | MMP1 | P03956 | 3/20 | 0.40 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9755065 | 1.00 | MME (0.81) | MMEECE1ACENPPAITGB1 | |
| Sampatrilat SCHEMBL4567110 | 0.90 | ECE1 (1.00) | MMEECE1ACENPPAITGB1 | |
| Sampatrilat SCHEMBL7301333 | 0.90 | ECE1 (1.00) | MMEECE1ACENPPAITGB1 | |
| Sampatrilat SCHEMBL49066 | 0.90 | ECE1 (1.00) | MMEECE1ACENPPAITGB1 | |
| SCHEMBL7294367 | 0.85 | ACE (0.91) | MMEECE1ACENPPAMMP1 | |
| SCHEMBL7302883 | 0.80 | MME (0.82) | MMEECE1ACENPPAITGB1 | |
| SCHEMBL7302871 | 0.80 | MME (0.82) | MMEECE1ACENPPAITGB1 | |
| SCHEMBL7300557 | 0.79 | MME (0.78) | MMEECE1ACENPPAITGB1 | |
| SCHEMBL7294361 | 0.79 | MME (0.80) | MMEECE1ACENPPA | |
| SCHEMBL6441043 | 0.78 | ACE (0.81) | MMEECE1ACENPPA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991013054-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE ANTIHYPERTENSIVE AGENTS | PFIZER LIMITED (GB) | 1991-09-05 | — | — | WO | disclosed |