Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | EDNRA | P25101 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295081 | 0.86 | GAA (0.52) | GAAHPGDALDH1A1EDNRAMAPT | |
| SCHEMBL4998200 | 0.77 | KMT2A (0.48) | GAAALDH1A1CYP2C19EDNRAMAPT | |
| SCHEMBL4997834 | 0.77 | ALDH1A1 (0.43) | GAAHPGDALDH1A1CYP2C19EDNRA | |
| SCHEMBL16809405 | 0.76 | ALDH1A1 (0.63) | GAAHPGDALDH1A1CYP2C19EDNRA | |
| SCHEMBL29896531 | 0.73 | ALDH1A1 (0.52) | GAAALDH1A1CYP2C19MAPTLMNA | |
| SCHEMBL4998310 | 0.73 | KMT2A (0.54) | ALDH1A1EDNRAMAPTLMNATP53 | |
| SCHEMBL14543573 | 0.73 | ALDH1A1 (0.41) | GAAHPGDALDH1A1CYP2C19EDNRA | |
| SCHEMBL7260564 | 0.72 | ALDH1A1 (0.52) | GAAHPGDALDH1A1CYP2C19EDNRA | |
| SCHEMBL7304734 | 0.72 | ALDH1A1 (0.54) | GAAALDH1A1CYP2C19MAPTLMNA | |
| SCHEMBL16468170 | 0.71 | LMNA (0.48) | HPGDALDH1A1CYP2C19EDNRAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5444083-A | DOPAMINE AGONIST FOR TREATING OR PREVENTION OF HYPERTENSION OR HEART FAILURE | EISAI CO., LTD. (JP) | 1995-08-22 | — | — | US | disclosed |
| EP-0381235-B1 | PYRROLIDINE COMPOUND AND PHARMACEUTICAL USE | Eisai Co., Ltd. (JP) | 1993-07-28 | — | — | EP | disclosed |
| EP-0381235-A2 | Pyrrolidine compound and pharmaceutical use | Eisai Co., Ltd. (JP) | 1990-08-08 | — | — | EP | disclosed |