Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299952 | 0.82 | POLB (0.75) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL7300653 | 0.81 | ALDH1A1 (0.55) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL20919593 | 0.76 | CYP1B1 (0.38) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL12005574 | 0.75 | POLB (1.00) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL4336239 | 0.74 | L3MBTL3 (0.69) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3574460 | 0.73 | MAPT (0.71) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL77340 | 0.73 | MAPT (0.71) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL10035919 | 0.72 | MAPT (0.51) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL521556 | 0.72 | KMT2A (0.64) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL1046692 | 0.71 | MEN1 (0.86) | POLBMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0503411-B1 | Substituted N-phenylpiperidines and medicaments thereof | BASF AG (DE) | 1995-11-29 | — | — | EP | disclosed |
| US-5296485-A | Substituted N-phenylpiperidines and drugs therefrom | BASF AKTIENGESELLSCHAFT (DE) | 1994-03-22 | — | — | US | disclosed |