Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | CBS | P35520 | 1/20 | 0.60 |
| ▸ | DPP4 | P27487 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.54 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | SHBG | P04278 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30065457 | 0.90 | GAA (0.66) | HTTTDP1CYP19A1GAAMAPT | |
| SCHEMBL7301852 | 0.90 | GAA (0.66) | HTTTDP1CYP19A1GAAMAPT | |
| SCHEMBL5793080 | 0.83 | CYP19A1 (0.65) | HTTCBSDPP4NPC1CASP3 | |
| SCHEMBL10350385 | 0.83 | HTT (0.83) | HTTNPC1RAB9AGAAMAPT | |
| SCHEMBL7773876 | 0.81 | HTT (0.80) | HTTNPC1RAB9AGAAMAPT | |
| SCHEMBL7775763 | 0.81 | HTT (0.80) | HTTNPC1RAB9AGAAMAPT | |
| SCHEMBL7775791 | 0.81 | HTT (0.80) | HTTNPC1RAB9AGAAMAPT | |
| SCHEMBL7769588 | 0.81 | HTT (0.80) | HTTNPC1RAB9AGAAMAPT | |
| SCHEMBL12896564 | 0.81 | HTT (0.80) | HTTNPC1RAB9AGAAMAPT | |
| Davidigenin SCHEMBL30291870 | 0.80 | CYP19A1 (0.70) | HTTNPC1RAB9ATDP1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151420-A | Cardiovascular disorders | ORION CORPORATION/ORION PHARMACEUTICA (FI) | 1992-09-29 | — | — | US | disclosed |
| EP-0359439-A1 | Substituted pyridazinones | ORION-YHTYMÄ OY (FI) | 1990-03-21 | — | — | EP | disclosed |