Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | CASP3 | P42574 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.62 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.62 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.61 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.61 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydrochalcone SCHEMBL29359372 | 0.89 | CYP19A1 (0.80) | CYP19A1NPC1TDP1RAB9AACHE | |
| Dihydrochalcone SCHEMBL2827303 | 0.89 | CYP19A1 (0.80) | CYP19A1NPC1TDP1RAB9AACHE | |
| Dihydrochalcone SCHEMBL7540273 | 0.87 | CYP19A1 (0.77) | CYP19A1NPC1TDP1RAB9AACHE | |
| SCHEMBL7295307 | 0.83 | HTT (0.60) | CYP19A1NPC1TDP1CASP3RAB9A | |
| SCHEMBL8670350 | 0.83 | CYP19A1 (0.59) | CYP19A1NPC1TDP1ACHESGMS1 | |
| SCHEMBL8672674 | 0.83 | CYP19A1 (0.59) | CYP19A1NPC1TDP1ACHESGMS1 | |
| SCHEMBL8519711 | 0.83 | CYP19A1 (0.59) | CYP19A1NPC1TDP1ACHESGMS1 | |
| SCHEMBL28161066 | 0.82 | ACHE (0.87) | NPC1TDP1CASP3RAB9ASENP8 | |
| SCHEMBL9077857 | 0.81 | HDAC3 (0.58) | CYP19A1NPC1TDP1RAB9AACHE | |
| SCHEMBL27617814 | 0.81 | NPC1 (0.53) | CYP19A1NPC1TDP1CASP3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006042007-A2 | CHROMENONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2006-04-20 | — | — | WO | disclosed |