Naringenin

Naringenin

SCHEMBL72954

O=C1CC(c2ccccc2)Oc2cccc(O)c21.O=C1C[C@@H](c2ccc(O)cc2)Oc2cc(O)cc(O)c21

nearest known ligand 0.81

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 6/20 0.81
CYP3A4 P08684 5/20 0.81
CYP1A1 P04798 4/20 0.81
CYP1A2 P05177 4/20 0.81
CYP1B1 Q16678 4/20 0.81
MAPT P10636 4/20 0.81
CYP2C19 P33261 3/20 0.81
HSD17B10 Q99714 3/20 0.81
MEN1 O00255 2/20 0.81
CYP2C9 P11712 2/20 0.81
KMT2A Q03164 2/20 0.81
CYP2D6 P10635 1/20 0.81
TTR P02766 3/20 0.79
CA12 O43570 2/20 0.79
SLCO2B1 O94956 2/20 0.79
CA4 P22748 2/20 0.79
PSMB5 P28074 2/20 0.79
CA7 P43166 2/20 0.79
TDP1 Q9NUW8 2/20 0.79
ALOX12 P18054 1/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Naringenin SCHEMBL1333765 0.91 CYP19A1 (0.81) CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1
Pinocembrin SCHEMBL291899 0.90 CYP19A1 (1.00) CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1
Pinocembrin SCHEMBL30186539 0.90 CYP19A1 (1.00) CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1
(R)-Pinocembrin SCHEMBL10080882 0.90 CYP19A1 (1.00) CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1
Pinocembrin SCHEMBL10026578 0.90 CYP19A1 (1.00) CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1
Pinocembrin SCHEMBL2484359 0.89 CYP19A1 (0.97) CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1
Naringenin SCHEMBL20570 0.89 CYP19A1 (1.00) CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1
Naringenin SCHEMBL1048136 0.89 CYP19A1 (1.00) CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1
Naringenin SCHEMBL20571 0.89 CYP19A1 (1.00) CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1
Naringenin SCHEMBL29351357 0.89 CYP19A1 (1.00) CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8129592-B2 Plant isoflavonoid hydroxylases and methods of use thereof THE SAMUEL ROBERTS NOBLE FOUNDATION, INC. (US) 2012-03-06 US disclosed
US-20090142471-A1 PLANT ISOFLAVONOID HYDROXYLASES AND METHODS OF USE THEREOF NOBLE RESEARCH INSTITUTE, LLC 2009-06-04 US disclosed
US-7442851-B2 Plant isoflavonoid hydroxylases and methods of use thereof THE SAMUEL ROBERTS NOBLE FOUNDATION (US) 2008-10-28 US disclosed
EP-1720986-A2 PLANT ISOFLAVONOID HYDROXYLASES AND METHODS OF USE THEREOF THE SAMUEL ROBERTS NOBLE FOUNDATION, INC. (US) 2006-11-15 EP disclosed
US-20050172354-A1 Plant isoflavonoid hydroxylases and methods of use thereof THE SAMUEL ROBERT NOBLE FOUNDATION 2005-08-04 US disclosed
WO-2005042747-A2 PLANT ISOFLAVONOID HYDROXYLASES AND METHODS OF USE THEREOF THE SAMUEL ROBERTS NOBLE FOUNDATION, INC. (US) 2005-05-12 WO disclosed