Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Pinocembrin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.97 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.80 |
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.80 |
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.80 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.80 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.65 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.65 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.97 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.97 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.97 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.97 |
| ▸ | MAPT | P10636 | 3/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.97 |
| ▸ | TTR | P02766 | 4/20 | 0.80 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pinocembrin SCHEMBL10026578 | 0.99 | CYP19A1 (1.00) | CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1 | |
| (R)-Pinocembrin SCHEMBL10080882 | 0.99 | CYP19A1 (1.00) | CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1 | |
| Pinocembrin SCHEMBL30186539 | 0.99 | CYP19A1 (1.00) | CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1 | |
| Pinocembrin SCHEMBL291899 | 0.99 | CYP19A1 (1.00) | CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1 | |
| Pinocembrin SCHEMBL2232882 | 0.96 | CYP19A1 (0.95) | CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1 | |
| Pinocembrin SCHEMBL3437711 | 0.92 | CYP19A1 (0.88) | CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1 | |
| Naringenin SCHEMBL30267460 | 0.90 | CYP19A1 (0.97) | CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1 | |
| Pinocembrin SCHEMBL17651823 | 0.89 | CYP19A1 (0.81) | CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1 | |
| Naringenin SCHEMBL1333765 | 0.89 | CYP19A1 (0.81) | CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1 | |
| Naringenin SCHEMBL72954 | 0.89 | CYP19A1 (0.81) | CYP19A1CYP3A4CYP1A1CYP1A2CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106963755-A | Application of the pinocembrin in demyelinating disease medicine is prepared | 中国人民解放军第二军医大学 | 2017-07-21 | — | — | CN | claimed |
| CN-102548626-A | Use of racemates of pinocembrin in preparing medicaments for treating stroke | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY SHIJIAZHUANG CO LTD | 2012-07-04 | — | — | CN | claimed |
| EP-2377529-A1 | USE OF RACEMATES OF PINOCEMBRIN IN PREPARING MEDICAMENTS FOR TREATING STROKE | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) | 2011-10-19 | — | — | EP | claimed |
| US-20110245334-A1 | USE OF RACEMATES OF PINOCEMBRIN IN PREPARING MEDICAMENTS FOR TREATING STROKE | CSPC Zhonggi Pharmaceutical Technology (Shijiazhuang) Co. Ltd. (CN) | 2011-10-06 | — | — | US | claimed |
| CN-101744806-A | Application of pinocembrin raceme in preparation of medicals for cerebral apoplexy | ZHONGQI PHARMACEUTICAL TECHNOLOGY SHIJIAZHUANG CO LTD | 2010-06-23 | — | — | CN | claimed |
| CN-106963755-B | Application of pinocembrin in preparation of drugs for treating demyelinating diseases | 中国人民解放军第二军医大学 | 2020-01-10 | — | — | CN | disclosed |
| CN-106963755-B | Application of pinocembrin in preparation of drugs for treating demyelinating diseases | 中国人民解放军第二军医大学 | 2020-01-10 | — | — | CN | disclosed |
| CN-106963755-A | Application of the pinocembrin in demyelinating disease medicine is prepared | 中国人民解放军第二军医大学 | 2017-07-21 | — | — | CN | disclosed |
| CN-106963755-A | Application of the pinocembrin in demyelinating disease medicine is prepared | 中国人民解放军第二军医大学 | 2017-07-21 | — | — | CN | disclosed |
| CN-101744806-B | Application of pinocembrin raceme in preparation of medicals for cerebral apoplexy | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY SHIJIAZHUANG CO LTD | 2012-09-12 | — | — | CN | disclosed |
| CN-101744806-B | Application of pinocembrin raceme in preparation of medicals for cerebral apoplexy | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY SHIJIAZHUANG CO LTD | 2012-09-12 | — | — | CN | disclosed |
| CN-102548626-A | Use of racemates of pinocembrin in preparing medicaments for treating stroke | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY SHIJIAZHUANG CO LTD | 2012-07-04 | — | — | CN | disclosed |
| EP-2377529-A1 | USE OF RACEMATES OF PINOCEMBRIN IN PREPARING MEDICAMENTS FOR TREATING STROKE | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) | 2011-10-19 | — | — | EP | disclosed |
| EP-2377529-A1 | USE OF RACEMATES OF PINOCEMBRIN IN PREPARING MEDICAMENTS FOR TREATING STROKE | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) | 2011-10-19 | — | — | EP | disclosed |
| US-20110245334-A1 | USE OF RACEMATES OF PINOCEMBRIN IN PREPARING MEDICAMENTS FOR TREATING STROKE | CSPC Zhonggi Pharmaceutical Technology (Shijiazhuang) Co. Ltd. (CN) | 2011-10-06 | — | — | US | disclosed |
| US-20110245334-A1 | USE OF RACEMATES OF PINOCEMBRIN IN PREPARING MEDICAMENTS FOR TREATING STROKE | CSPC Zhonggi Pharmaceutical Technology (Shijiazhuang) Co. Ltd. (CN) | 2011-10-06 | — | — | US | disclosed |
| CN-101744806-A | Application of pinocembrin raceme in preparation of medicals for cerebral apoplexy | ZHONGQI PHARMACEUTICAL TECHNOLOGY SHIJIAZHUANG CO LTD | 2010-06-23 | — | — | CN | disclosed |
| CN-101744806-A | Application of pinocembrin raceme in preparation of medicals for cerebral apoplexy | ZHONGQI PHARMACEUTICAL TECHNOLOGY SHIJIAZHUANG CO LTD | 2010-06-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245334-A1 | USE OF RACEMATES OF PINOCEMBRIN IN PREPARING MEDICAMENTS FOR TREATING STROKE | CROCC, PNN, ZMPSTE24 | MEN1 3524/4885ESR1 4790/4885DPP4 552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.