Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 3/20 | 0.40 |
| ▸ | EDNRB | P24530 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7296272 | 0.86 | DHPS (0.42) | DHPSTRPA1NPBWR1MCHR1 | |
| SCHEMBL1937757 | 0.86 | EDNRA (0.49) | DHPSEDNRAEDNRBCYP19A1 | |
| SCHEMBL7300009 | 0.84 | DHPS (0.51) | DHPSL3MBTL1TRPA1EDNRANPBWR1 | |
| SCHEMBL1257596 | 0.77 | DHPS (0.52) | DHPSEDNRAEDNRB | |
| SCHEMBL7942227 | 0.74 | HPGD (0.45) | L3MBTL1EDNRAEDNRBCYP19A1 | |
| SCHEMBL9423634 | 0.74 | FFAR1 (0.51) | L3MBTL1 | |
| SCHEMBL29685386 | 0.70 | SYK (0.50) | L3MBTL1TRPA1CYP19A1 | |
| SCHEMBL5035340 | 0.70 | DHPS (0.43) | DHPS | |
| SCHEMBL28568819 | 0.70 | DHPS (0.59) | DHPS | |
| SCHEMBL4061462 | 0.70 | DHPS (0.49) | DHPSEDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |