Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 14/20 | 0.51 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29770374 | 0.86 | DHPS (0.58) | DHPSEDNRA | |
| SCHEMBL618135 | 0.86 | DHPS (0.58) | DHPSEDNRA | |
| SCHEMBL7296266 | 0.84 | DHPS (0.43) | DHPSNPBWR1MCHR1L3MBTL1TRPA1 | |
| SCHEMBL7294883 | 0.82 | DHPS (0.50) | DHPSNPBWR1MCHR1TRPA1 | |
| SCHEMBL7303200 | 0.80 | NPBWR1 (0.48) | DHPSNPBWR1MCHR1TRPA1 | |
| SCHEMBL28584109 | 0.79 | DHPS (0.65) | DHPS | |
| SCHEMBL7795451 | 0.78 | DHPS (0.53) | DHPSEDNRA | |
| SCHEMBL7305726 | 0.78 | EDNRA (0.63) | DHPSEDNRA | |
| SCHEMBL4064097 | 0.77 | DHPS (0.74) | DHPS | |
| SCHEMBL1257596 | 0.77 | DHPS (0.52) | DHPSEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |