Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | ATP1A1 | P05023 | 6/20 | 0.42 |
| ▸ | ATP1B1 | P05026 | 6/20 | 0.42 |
| ▸ | ATP1A3 | P13637 | 6/20 | 0.42 |
| ▸ | ATP1B2 | P14415 | 6/20 | 0.42 |
| ▸ | ATP1A2 | P50993 | 6/20 | 0.42 |
| ▸ | ATP1B3 | P54709 | 6/20 | 0.42 |
| ▸ | FXYD2 | P54710 | 6/20 | 0.42 |
| ▸ | ATP1A4 | Q13733 | 6/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SHBG | P04278 | 1/20 | 0.41 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297224 | 1.00 | CYP19A1 (0.43) | CYP19A1ATP1A1ATP1B1ATP1A3ATP1B2 | |
| SCHEMBL4340293 | 1.00 | CYP19A1 (0.43) | CYP19A1ATP1A1ATP1B1ATP1A3ATP1B2 | |
| SCHEMBL1115709 | 0.89 | GPBAR1 (0.35) | GPBAR1 | |
| SCHEMBL1115738 | 0.89 | GPBAR1 (0.35) | GPBAR1 | |
| SCHEMBL22105689 | 0.85 | GPBAR1 (0.46) | GPBAR1LMNA | |
| SCHEMBL25322998 | 0.84 | LMNA (0.59) | CYP19A1GPBAR1LMNASHBGSERPINA6 | |
| SCHEMBL25326883 | 0.84 | LMNA (0.59) | CYP19A1GPBAR1LMNASHBGSERPINA6 | |
| SCHEMBL25912307 | 0.84 | LMNA (0.59) | CYP19A1GPBAR1LMNASHBGSERPINA6 | |
| SCHEMBL25323572 | 0.84 | LMNA (0.59) | CYP19A1GPBAR1LMNASHBGSERPINA6 | |
| SCHEMBL25912457 | 0.84 | LMNA (0.59) | CYP19A1GPBAR1LMNASHBGSERPINA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825197-B1 | New 6-hydroxy and 6-oxo-androstane derivatives active on the cardiovascular system and pharmaceutical compositions containing same | SIGMA TAU IND FARMACEUTI (IT) | 2000-10-04 | — | — | EP | disclosed |
| US-5914324-A | HYPOTENSIVE AGENTS, TREATMENT OF CARDIAC FAILURE | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1999-06-22 | — | — | US | disclosed |
| EP-0825197-A2 | New 6-hydroxy and 6-oxo-anstro-stane derivatives active on the cardiovascular system and pharmaceutical compositions containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1998-02-25 | — | — | EP | disclosed |