Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PPM1D | O15297 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1115709 | 1.00 | GPBAR1 (0.35) | GPBAR1MAPTTHRBPPM1D | |
| SCHEMBL7296344 | 0.89 | CYP19A1 (0.43) | GPBAR1 | |
| SCHEMBL4340293 | 0.89 | CYP19A1 (0.43) | GPBAR1 | |
| SCHEMBL7297224 | 0.89 | CYP19A1 (0.43) | GPBAR1 | |
| SCHEMBL22105689 | 0.84 | GPBAR1 (0.46) | GPBAR1MAPTTHRB | |
| SCHEMBL1115367 | 0.84 | CYP2C19 (0.36) | MAPTPPM1D | |
| SCHEMBL1115659 | 0.84 | CYP2C19 (0.36) | MAPTPPM1D | |
| SCHEMBL20012021 | 0.81 | L3MBTL1 (0.35) | GPBAR1PPM1D | |
| SCHEMBL20011997 | 0.81 | L3MBTL1 (0.35) | GPBAR1PPM1D | |
| SCHEMBL19125014 | 0.81 | L3MBTL1 (0.35) | GPBAR1PPM1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022203-B2 | Amino derivatives of beta-homoandrostanes and beta-heteroandrostanes | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2011-09-20 | — | — | US | disclosed |
| EP-2032593-B1 | AMINO DERIVATIVES OF B-HOMOANDROSTANES AND B-HETEROANDROSTANES | SIGMA TAU IND FARMACEUTI (IT) | 2011-02-02 | — | — | EP | disclosed |
| US-20090209506-A1 | AMINO DERIVATIVES OF BETA-HOMOANDROSTANES AND BETA-HETEROANDROSTANES | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2009-08-20 | — | — | US | disclosed |
| EP-2032593-A1 | AMINO DERIVATIVES OF B-HOMOANDROSTANES AND B-HETEROANDROSTANES | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007147713-A1 | AMINO DERIVATIVES OF B-HOMOANDROSTANES AND B-HETEROANDROSTANES | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209506-A1 | AMINO DERIVATIVES OF BETA-HOMOANDROSTANES AND BETA-HETEROANDROSTANES | CYP11B2, PTGIS, PTGER1 | GPBAR1 91/4885MAPT 4808/4885THRB 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.