Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.69 |
| ▸ | HTR2C | P28335 | 5/20 | 0.69 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.59 |
| ▸ | HTR3B | O95264 | 1/20 | 0.59 |
| ▸ | HTR3A | P46098 | 1/20 | 0.59 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.59 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7296771 | 0.82 | HTR1A (1.00) | HTR1AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL8567429 | 0.81 | HTR3E (0.75) | HTR1AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL7295524 | 0.81 | HTR1A (1.00) | HTR1AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL7306033 | 0.78 | HTR2C (1.00) | HTR1AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL8571641 | 0.76 | HTR3E (0.64) | HTR1AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL8566903 | 0.75 | HTR3E (1.00) | HTR1AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL7296823 | 0.74 | HTR2C (0.75) | HTR1AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL7305295 | 0.72 | HTR2C (0.63) | HTR1AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL1753190 | 0.67 | KMT2A (0.66) | KMT2AMEN1ATMKDM4EALDH1A1 | |
| SCHEMBL13033531 | 0.67 | SMO (0.55) | KMT2AMEN1ATMKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573360-B1 | Pyrrolothienopyrazine compounds as 5-HT3 receptors antagonists | ADIR (FR) | 1998-08-26 | — | — | EP | disclosed |
| EP-0573360-A1 | Pyrrolothienopyrazine compounds as 5-HT3 receptors antagonists | ADIR ET COMPAGNIE (FR) | 1993-12-08 | — | — | EP | disclosed |