Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 11/20 | 1.00 |
| ▸ | HTR1A | P08908 | 9/20 | 1.00 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.61 |
| ▸ | HTR3B | O95264 | 4/20 | 0.61 |
| ▸ | HTR3A | P46098 | 4/20 | 0.61 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.61 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.61 |
| ▸ | PRKCI | P41743 | 2/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7296771 | 0.86 | HTR1A (1.00) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL7298138 | 0.83 | HTR2C (0.74) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL7296823 | 0.79 | HTR2C (0.75) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL7305295 | 0.78 | HTR2C (0.63) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL7296996 | 0.78 | HTR1A (0.69) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL7299090 | 0.76 | HTR1A (1.00) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL7301139 | 0.72 | HTR1A (0.91) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL8564852 | 0.72 | HTR2C (0.63) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL8562640 | 0.70 | HTR2C (0.69) | HTR2CHTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL8564626 | 0.70 | HTR3E (0.75) | HTR2CHTR1AHTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573360-B1 | Pyrrolothienopyrazine compounds as 5-HT3 receptors antagonists | ADIR (FR) | 1998-08-26 | — | — | EP | disclosed |
| EP-0573360-A1 | Pyrrolothienopyrazine compounds as 5-HT3 receptors antagonists | ADIR ET COMPAGNIE (FR) | 1993-12-08 | — | — | EP | disclosed |