Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.71 |
| ▸ | APP | P05067 | 4/20 | 0.64 |
| ▸ | XDH | P47989 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7823812 | 0.84 | MAOB (0.63) | MAOBXDHPOLB | |
| SCHEMBL29873198 | 0.84 | APP (0.82) | MAOBAPPALDH1A1MAPTNPC1 | |
| SCHEMBL14833013 | 0.84 | APP (0.82) | MAOBAPPALDH1A1MAPTNPC1 | |
| SCHEMBL2535418 | 0.83 | XDH (0.86) | MAOBXDHALDH1A1MAPTNPC1 | |
| SCHEMBL4985411 | 0.83 | ALDH1A1 (0.76) | MAOBAPPALDH1A1MAPTNPC1 | |
| SCHEMBL14900899 | 0.81 | TNKS (0.59) | MAOBMAPTNPC1RAB9AMEN1 | |
| SCHEMBL11844763 | 0.80 | APP (0.75) | MAOBAPPALDH1A1MAPTNPC1 | |
| SCHEMBL10172976 | 0.79 | APP (0.54) | MAOBAPPALDH1A1MAPTNPC1 | |
| SCHEMBL10172975 | 0.79 | GABRP (0.69) | MAOBMAPTNPC1RAB9AMEN1 | |
| SCHEMBL13191536 | 0.79 | MAOB (0.54) | MAOBMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120189545-A1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS | UNIVERSITY OF PITTSBURGH -- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2012-07-26 | — | — | US | disclosed |
| US-20120148494-A1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS | UNIVERSITY OF PITTSBURGH -- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2012-06-14 | — | — | US | disclosed |
| US-8138360-B2 | substrates for amyloidogenic proteins, for example, A beta 1-42, an amyloid protein, brain deposits of which are associated with Alzheimer's disease | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2012-03-20 | — | — | US | disclosed |
| US-8138360-B2 | substrates for amyloidogenic proteins, for example, A beta 1-42, an amyloid protein, brain deposits of which are associated with Alzheimer's disease | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2012-03-20 | — | — | US | disclosed |
| US-8138360-B2 | substrates for amyloidogenic proteins, for example, A beta 1-42, an amyloid protein, brain deposits of which are associated with Alzheimer's disease | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2012-03-20 | — | — | US | disclosed |
| US-20080274058-A1 | Isotopically-Labeled Benzofuran Compounds as Imaging Agents for Amyloidogenic Proteins | UNIVERSITY OF PITTSBURGH- OF COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2008-11-06 | — | — | US | disclosed |
| US-20080274058-A1 | Isotopically-Labeled Benzofuran Compounds as Imaging Agents for Amyloidogenic Proteins | UNIVERSITY OF PITTSBURGH- OF COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2008-11-06 | — | — | US | disclosed |
| EP-1945622-A1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGINGAGENTS FORAMYLOIDOGENIC PROTEINS | The University of Pittsburgh (US) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007047204-A1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGINGAGENTS FORAMYLOIDOGENIC PROTEINS | UNIVERSITY OF PITTSBURGH (US) | 2007-04-26 | — | — | WO | disclosed |
| WO-2007047204-A1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGINGAGENTS FORAMYLOIDOGENIC PROTEINS | UNIVERSITY OF PITTSBURGH (US) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120148494-A1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS | BACE1, APP, BACE2 | MAOB 1812/4885APP 2/4885XDH 3105/4885 |
| US-20080274058-A1 | Isotopically-Labeled Benzofuran Compounds as Imaging Agents for Amyloidogenic Proteins | BACE1, APP, BACE2 | MAOB 1693/4885APP 2/4885XDH 2764/4885 |
| US-20120189545-A1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS | BACE1, APP, BACE2 | MAOB 1693/4885APP 2/4885XDH 2764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.