Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10878299 | 0.97 | TP53 (0.47) | ALDH1A1TP53TSHRMEN1KMT2A | |
| SCHEMBL10754391 | 0.87 | ALDH1A1 (0.53) | ALDH1A1TP53TSHRMEN1KMT2A | |
| SCHEMBL732382 | 0.85 | TDP1 (0.56) | ALDH1A1TP53TSHRMEN1KMT2A | |
| SCHEMBL11852793 | 0.84 | ALDH1A1 (0.53) | ALDH1A1TP53TSHRMEN1KMT2A | |
| SCHEMBL14517852 | 0.82 | ALDH1A1 (0.54) | ALDH1A1TP53TSHRMEN1KMT2A | |
| SCHEMBL4902039 | 0.82 | ALDH1A1 (0.57) | ALDH1A1TP53TSHRMEN1KMT2A | |
| SCHEMBL4081261 | 0.82 | ALDH1A1 (0.57) | ALDH1A1TP53TSHRMEN1KMT2A | |
| SCHEMBL22837931 | 0.81 | TDP1 (0.51) | ALDH1A1TP53TSHRMEN1KMT2A | |
| SCHEMBL19771016 | 0.80 | ACACB (0.48) | MEN1KMT2AMAPTHPGDCYP1A2 | |
| SCHEMBL3431470 | 0.80 | LMNA (0.51) | ALDH1A1TP53TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |
| EP-0207036-A1 | New para-substituted 3-phenoxy-1-piperidinecarbonylaminoalkylamino-propanol-2-s having beta receptor blocking properties. | Aktiebolaget Hässle (SE) | 1986-12-30 | — | — | EP | disclosed |