Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.33 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 11/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301405 | 0.89 | HTR2C (0.40) | HTR2CKCNE1KCNQ1TRPV1AKR1B1 | |
| SCHEMBL7294955 | 0.78 | HTR2C (0.42) | HTR2CDRD2HTR2AKCNE1KCNQ1 | |
| SCHEMBL7298872 | 0.77 | KCNE1 (0.37) | DRD2KCNE1KCNQ1CYP3A4 | |
| SCHEMBL7300502 | 0.76 | TSHR (0.37) | HTR2CCYP3A4 | |
| SCHEMBL9585167 | 0.75 | CA9 (0.40) | AKR1B1CYP3A4 | |
| SCHEMBL9983051 | 0.73 | ADRA2A (0.38) | KCNE1KCNQ1TRPV1AKR1B1 | |
| SCHEMBL7297848 | 0.70 | KCNE1 (0.35) | HTR2CKCNE1KCNQ1TRPV1AKR1B1 | |
| SCHEMBL3322611 | 0.69 | MAPT (0.43) | HTR2A | |
| SCHEMBL7297208 | 0.69 | KCNE1 (0.35) | DRD2KCNE1KCNQ1CYP3A4 | |
| SCHEMBL7290026 | 0.68 | HTR2C (0.42) | HTR2CKCNE1KCNQ1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260444-A | Cardiovascular, hypotensive | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1993-11-09 | — | — | US | disclosed |
| US-5208245-A | Hypotensive agents | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1993-05-04 | — | — | US | disclosed |
| EP-0460418-A2 | Novel Dihydropyridine derivative | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1991-12-11 | — | — | EP | disclosed |