Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.36 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3191931 | 0.96 | RAB9A (0.41) | SMN1; SMN2RAB9AGGPS1MEN1KMT2A | |
| SCHEMBL7294672 | 0.89 | CYP3A4 (0.46) | SMN1; SMN2MEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL7333223 | 0.89 | MEN1 (0.40) | SMN1; SMN2MEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL16892572 | 0.89 | TDP1 (0.41) | SMN1; SMN2RAB9AMEN1KMT2AUSP2 | |
| SCHEMBL7293751 | 0.89 | SMN1; SMN2 (0.34) | SMN1; SMN2RAB9AMEN1KMT2AUSP2 | |
| SCHEMBL7298307 | 0.87 | ALDH1A1 (0.45) | SMN1; SMN2MEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL7304240 | 0.87 | ALDH1A1 (0.44) | SMN1; SMN2MEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL7294183 | 0.87 | HRH3 (0.39) | SMN1; SMN2MEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL7295179 | 0.86 | MEN1 (0.48) | SMN1; SMN2MEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL7327631 | 0.85 | ALDH1A1 (0.43) | SMN1; SMN2MEN1KMT2AUSP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |