Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | NR3C2 | P08235 | 9/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300845 | 0.92 | LMNA (0.58) | LMNANR3C2NR3C1MGLLHCRTR2 | |
| SCHEMBL7299169 | 0.89 | LMNA (0.58) | LMNANR3C2NR3C1PGRCTNNB1 | |
| SCHEMBL8548928 | 0.89 | LMNA (0.60) | LMNANR3C2NR3C1PGRCTNNB1 | |
| SCHEMBL7305217 | 0.88 | LMNA (0.72) | LMNANR3C2NR3C1PGRCTNNB1 | |
| SCHEMBL7301526 | 0.86 | LMNA (0.62) | LMNANR3C2NR3C1PGRCTNNB1 | |
| SCHEMBL7302522 | 0.85 | LMNA (0.54) | LMNANR3C2NR3C1PGRCTNNB1 | |
| SCHEMBL8544144 | 0.85 | LMNA (0.53) | LMNANR3C2NR3C1MGLLHCRTR2 | |
| SCHEMBL7302004 | 0.84 | LMNA (0.55) | LMNANR3C2NR3C1MGLL | |
| SCHEMBL7301998 | 0.84 | LMNA (0.53) | LMNANR3C2NR3C1MGLLHCRTR2 | |
| SCHEMBL7305178 | 0.83 | LMNA (0.58) | LMNANR3C2NR3C1PGRCTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666260-B1 | 3-(2-aminoethyl)-4-3-(trifluoromethyl)benzoyl-3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and use in therapy | SYNTHELABO (FR) | 1999-08-04 | — | — | EP | disclosed |
| EP-0614893-B1 | Benzoxazine derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1998-05-27 | — | — | EP | disclosed |
| US-5550125-A | BRAIN DISORDERS | SYNTHELABO (FR) | 1996-08-27 | — | — | US | disclosed |
| US-5447928-A | Antiischemic agents and nervous system disorders | SYNTHELABO (FR) | 1995-09-05 | — | — | US | disclosed |
| EP-0666260-A1 | 3-(2-aminoethyl)-4-3-(trifluoromethyl)benzoyl-3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and use in therapy | SYNTHELABO (FR) | 1995-08-09 | — | — | EP | disclosed |
| EP-0614893-A1 | Benzoazine derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1994-09-14 | — | — | EP | disclosed |