Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304570 | 0.92 | LMNA (0.61) | LMNAMEN1KMT2APOLBGAA | |
| SCHEMBL8548928 | 0.88 | LMNA (0.60) | LMNAMEN1KMT2APOLBNR3C1 | |
| SCHEMBL7299169 | 0.87 | LMNA (0.58) | LMNAMEN1KMT2APOLBNR3C1 | |
| SCHEMBL7298261 | 0.86 | LMNA (0.58) | LMNAMEN1KMT2APOLBNR3C1 | |
| SCHEMBL7305217 | 0.86 | LMNA (0.72) | LMNAMEN1KMT2APOLBGAA | |
| SCHEMBL7299798 | 0.85 | LMNA (0.56) | LMNAMEN1KMT2APOLBGAA | |
| SCHEMBL7299793 | 0.85 | LMNA (0.59) | LMNAMEN1KMT2APOLBGAA | |
| SCHEMBL7302522 | 0.83 | LMNA (0.54) | LMNAMEN1KMT2APOLBNR3C1 | |
| SCHEMBL8547759 | 0.80 | LMNA (0.59) | LMNAMEN1KMT2APOLBNR3C1 | |
| SCHEMBL7300845 | 0.79 | LMNA (0.58) | LMNAMEN1KMT2APOLBNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666260-B1 | 3-(2-aminoethyl)-4-3-(trifluoromethyl)benzoyl-3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and use in therapy | SYNTHELABO (FR) | 1999-08-04 | — | — | EP | disclosed |
| US-5550125-A | BRAIN DISORDERS | SYNTHELABO (FR) | 1996-08-27 | — | — | US | disclosed |
| EP-0666260-A1 | 3-(2-aminoethyl)-4-3-(trifluoromethyl)benzoyl-3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and use in therapy | SYNTHELABO (FR) | 1995-08-09 | — | — | EP | disclosed |